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Such findings highlight epigenetic regulation as a promising avenue for identifying new therapeutic targets for addiction

379 Current researches have demonstrated that the mechanisms of systemic IR and brain-specific IR have close links with AD pathogenesis

In terms of antioxidant defense, it not only directly scavenges free radicals (Singh et al., 2011) but also activates the Nrf2/ARE axis (Ashrafizadeh et al., 2020), driving the expression of key enzymes such as glutathione S-transferase and catalase to systemically alleviate ROS accumulation

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